Pemberian Minuman dan Cookies Galohgor Terhadap Kadar Blood Urea Nitrogen (Bun) dan Kreatinin Plasma Penderita Diabetes Melitus Tipe 2
The Effect of Drinks and Cookies Contained Galohgor on Blood Urea Nitrogen (BUN) and Creatinine Plasma in Type 2 Diabetic Subjects
DOI:
https://doi.org/10.35473/jgk.v12i1.75Keywords:
BUN, DM tipe 2, Galohgor, kreatinin plasmaAbstract
The aim of this research was to analyze the effect of drinks and cookies contained Galohgor extract on Blood Urea Nitrogen (BUN) and creatinine plasma in type 2 diabetic subjects. This study used single blind Randomized Control Trial (RCT) with cross-over design applied on 11 type 2 diabetic subjects in Cikarawang, Babakan and Balumbang Jaya Village-Dramaga, Bogor District, West Java. Each subject received powdered drinks and cookies contained Galohgor extract 2 grams/day (1 gram of Galohgor extract in the form of drink 8 grams and 1 gram of Galohgor extract in the form of cookies 24 grams) and without Galohgor extract (control) for 38 days treatment with four wash-out period between treatment periods. BUN and creatinine levels were conducted by plasma blood sample at pre and post intervention. The result showed that the different levels of BUN between post and pre intervention for Galohgor group compared to control group were -4,9±11,2 mg/dL and -9,6±12,5 mg/dL (p>0,05). The different levels of creatinine between post and pre intervention for Galohgor group compared to control group were -0,1±0,2 mg/dL and -0,1±0,2 mg/dL (p>0,05). Therefore, drinks and cookies contained Galohgor extract 2 gram/day does not affect the BUN and creatinine level of type 2 diabetic subjects.
Abstrak :
Penelitian ini bertujuan untuk menganalisis pengaruh minuman dan cookies Galohgor terhadap kadar Blood Urea Nitrogen (BUN) dan kadar kreatinin plasma penderita DM tipe 2. Jenis penelitian ini adalah single blind Randomized Control Trial (RCT) dengan desain cross-over pada 11 subjek DM tipe 2 yang dilakukan di desa Cikarawang, Babakan dan Balumbang Jaya, Kecamatan Dramaga, Kabupaten Bogor, Jawa Barat. Masing-masing subjek mendapatkan minuman dan cookies yang mengandung ekstrak Galohgor sebesar 2 gram/hari (1 gram ekstrak Galohgor dalam bentuk 8 gram minuman serbuk dan 1 gram ekstrak Galohgor dalam bentuk 24 gram cookies) dan minuman serbuk dan cookies tanpa ekstrak Galohgor (kontrol) selama 38 hari dengan empat bulan periode wash-out antar perlakuan. Kadar BUN dan kreatinin dikumpulkan dari sampel plasma darah pada sebelum dan setelah intervensi. Hasil penelitian menunjukkan rata-rata selisih kadar BUN pada kelompok Galohgor dibandingkan dengan kelompok kontrol yaitu -4,9±11,2 mg/dL dan -9,6±12,5 mg/dL (p>0,05). Kadar kreatinin pada kelompok Galohgor dibandingkan dengan kelompok Galohgor yaitu -0,1±0,2 mg/dL dan -0,1±0,2 mg/dL (p>0,05). Oleh karena itu, pemberian minuman dan cookies yang mengandung ekstrak Galohgor 2 gram/hari tidak berpengaruh terhadap kadar ureum dan kreatinin penderita DM tipe 2.
Downloads
References
[ADA] American Diabetes and Assosiation. 2014. Diagnosis and classification of diabetes mellitus. Diabetes Care; 37 (Suplement 1), S81-S90.
Asmat U, Abad K, Ismail K. 2016. Diabetes mellitus and oxidative stress—a concise review. Saudi Pharmaceutical Journal; 24(5): 547-553.
Baldi A, Choudhary N, Kumar, S. 2013. Nutraceuticals as therapeutic agents for holistic treatment of diabetes. International Journal of Green Pharmacy;7(4):278.
Bandeira S, Fonseca L, Guedes L, Rabelo L, Goulart M, Vasconcelos S. 2013. Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus (review). Int. J. Mol. Sci; 14(2): 3265-3284. doi:10.3390/ijms14023265.
C Lidiane Jácome de Lima, Patrícia Simplício de Oliveira, Thalys Maynnard Costa Ferreira, Eliane Cristina da Silva, Josefa Danielma Lopes Ferreira, Rossana Santos de Andrade, Yanny Dantas de Macedo, Williane Leôncio Gomes, Eduardo Gomes de Melo, Adriana Lira Rufino de Lucena et al. 2016. Risk Factors for Type II Diabetes Mellitus: an Integrative Review. International Archives of Medicine; 9(308).1-11.doi: 10.3823/2179.
Chow SC, Shao J, Wang H. 2008. Sample Size Calculations in Clinical Research 2nd ed. USA: CRC Press.
Dabla PK. 2010. Renal function in diabetic nephropathy. World journal of diabetes; 1(2):48-56.
Elliot R. 2005. Mechanisms of genomic and non-genomic actions of carotenoids (Review). Bioch Biophysica Acta (BBA); 740(2):147-154.
Firdaus, Rimbawan, Marliyati SA, Roosita K. 2016. Peran nutrasetikal Galohgor dalam mempertahankan berat badan dan menurunkan glukosa darah pada tikus diabetes yang diinduksi streptozotocin. Jurnal Aplikasi Teknologi Pangan; 5(3).45-48. http://dx.doi.org/10.1772.
Goel S, Kaur. 2013. Impact of hyphoglicemic herbal mixture based biscuits intervention on blood glucose level and lipid profile of type 2 diabetic subjects. International Journal of Food and Nutritional Science; 2(2):84-90.
[IDF] International Diabetes Federation. 2019. IDF Diabetes atlas. Ed ke-9. http://www. diabetesatlas. org.
Leatemia Rosalin Ravensca. 2010. Aktivitas antioksidan jamu galohgor pada tikus putih (Rattus sp.) [tesis]. Bogor (ID): Institut Pertanian Bogor.
Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J. 2012. The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos University Medical Journal 12(1): 5-18
Meyer C, Dostou JM, Welle SL, Gerich JE. 2002. Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. American Journal of Physiology-Endocrinology And Metabolism 282(2):419-427.
Nasri Hamid, Azar Baradaran, Hedayatollah Shirzad, Mahmoud Rafieian-Kopaei2. 2014. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med; 5(12):1487–1499.
[PERKENI] Perkumpulan Endokrinologi Indonesia. 2015. Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. Jakarta (ID): PERKENI.
Ramatina, Amalia L, Ekayanti I. 2014. Pengaruh suplementasi antioksidan terhadap kadar malondialdehid plasma mahasiswa IPB. J Gizi dan Pangan; 9(1): 35-42.
Rani AJ, Mythili SV. 2012 Study on Total Antioxidant Status in Relation to Oxidative Stress in Type 2 Diabetes Mellitus. J Clin Diagn Res; 8(3):108-118.
[Riskesdas] Riset Kesehatan Dasar. 2018. Laporan Nasional. Jakarta: Badan Penelitian dan Pengembangan Kesehatan, Departemen Kesehatan RI.
Roosita K, Kusharto CM, Sekiyama M, Ohtsuka R. 2006. Penggunaan tanaman obat oleh pengobat tradisional di desa Sukajadi wilayah hutan wisata curug Nangka Bogor. Media Gizi dan Keluarga; 30(1):77-87.
______, Rimbawan S M, Djuwita I, Damanik MR, Kusharto CM, Damayanthi E, Nomura N. 2014. β-carotene roles in proliferation and differentiation, connexin and β-casein gene expression of mammary gland cells line. Malaysian Journal of Nutrition 20(1):113-119.
______, Rimbawan, Marliyati S A, Damayati R P, Setyaningsih S, Ratnadiyanti A. 2016. Intervensi nutrasetikal galohgor untuk penanggulangan diabetes melitus [laporan penelitian yang tidak diterbitkan]. Bogor (ID). Institut Pertanian Bogor.
Salgado JV. Neves FA, Bastos MG, França AK, Brito DJ, Santos EMD, Salgado Filho N. 2010. Monitoring renal function: measured and estimated glomerular filtration rates-a review. Brazilian Journal of Medical and Biological Research; 43(6):528-536.
Sandilands EA, Dhaun N, Dear JW, Webb DJ. 2013. Measurement of renal function in patients with chronic kidney disease. British journal of clinical pharmacology; 76(4):504-515.
Setyaningsih S, Roosita K, Damayanthi E. 2017. Efek produk galohgor terhadap aktivitas antioksidan dan penurunan stres oksidatif pada penderita diabetes melitus tipe 2. Media Kesehatan Masyarakat Indonesia; 13(4): 310-318.
Suharmiati, Roosihermiatie B. 2012. Studi pemanfaatan dan keamanan kombinasi metformin dengan ekstrak campuran Andrographis panicula dan Syzygum polyanthum untuk pengobatan diabetes mellitus (preliminary study). Buletin Penelitian Sistem Kesehatan 15(2):110–119.
Vuksan V1, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, Lee KS, Leiter LA, Nam KY, Arnason JT, Choi M, Naeem A. 2008. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis; 18(1):46-56.
Zatalia SR, Sanusi H. 2013. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Med Indones; 45(2):141-147.
